Oral tolerance

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Oral glucose tolerance testing.

The oral glucose tolerance test (OGTT) is currently the gold standard for the diagnosis of diabetes. The recommended preparation for and administration of the OGTT are important to ensure that test results are not affected. Interpretation is based on venous plasma glucose results before and 2 hours after a 75 g oral glucose load.

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Development of Oral Tolerance

"Oral (food) tolerance" usually describes a clinical situation that is not necessarily synonymous with the immunological definition of "tolerance," that is, as observed during development, transplantation or neonatal tolerance. In the context of this chapter, "oral tolerance" is defined as an antigen-specific immunological hyporesponsiveness after prior enteral administration. Oral exposure to ...

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Oral iron tolerance.

The tolerance of volunteer patients to various ferrous salt preparations, administered orally in equivalent doses of elemental iron, has been compared. The palatability of ferrous sulphate tablets, BP, given before meals was not improved by administration after meals, by sustained release formulation, or by substituting other ferrous salts. Intolerance was related to the number of tablets rathe...

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Mechanisms of oral tolerance revisited

Oral tolerance induction is thought to depend on special antigen presenting cells in the gut. A new report in the previous issue of Arthritis Research & Therapy supports this idea by demonstrating that indoleamine 2,3-dioxygenase-expressing dendritic cells in Peyer's patches from orally tolerized mice suppress T-cell responses via the generation of CD4+CD25+ regulatory T cells. This finding pro...

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Prediction of Glucose Tolerance without an Oral Glucose Tolerance Test

Introduction Impaired glucose tolerance (IGT) is diagnosed by a standardized oral glucose tolerance test (OGTT). However, the OGTT is laborious, and when not performed, glucose tolerance cannot be determined from fasting samples retrospectively. We tested if glucose tolerance status is reasonably predictable from a combination of demographic, anthropometric, and laboratory data assessed at one ...

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ژورنال

عنوان ژورنال: Immunological Reviews

سال: 2011

ISSN: 0105-2896

DOI: 10.1111/j.1600-065x.2011.01017.x